The CFS 1200 Video
A System of Filling and Batch Manufacturing
CFS Liquid Filling and Sealing Machines
The CFS capsule liquid filling and sealing systems are specifically designed to allow formulation scientists to better exploit the potential of lipid-based formulations for poorly soluble compounds, helping accelerate the development timeline and achieve ‘faster time to first in human’.
Options to Meet Your Needs
The CFS 1200 system is a bench-top cGMP-compliant machine that fills up to 1,200 capsules per hour with liquid or semi-solid formulations using Capsugel’s proprietary Liquid Encapsulation Microspray Sealing (LEMS®) technology and eliminating the need for banding. We also offer a mobile, floor-standing machine, the CFS 1500c system, which fills capsules at a rate of up to 1,500 per hour.
“It (CFS 1200) has more than paid for itself in terms of saving the cost of contract development work and clinical manufacturing”.
- Pharmaceutical Company
To read more customer testimonials, click here.
CFS 1200 Liquid Filling and Sealing Machine
This high-precision, cGMP compliant, development-scale capsule filling machine automatically fills and seals two-piece capsules with liquid or semi-solid formulations, suspensions and emulsions. Specially designed to produce trial and clinical batches with Licaps® capsules, the CFS 1200 can help accelerate the development timeframe to achieve faster time to first in human. Key features include:
- Bench-top machine perfect for R&D labs
- Liquid filling and sealing with one automatic machine
- Handles both liquids and semi-solids
- Accurate dosing from 0.1 - 1.2 ml
- Designed for ease of use and high reliability, with the ability to quickly clean and change capsule sizes with optional parts
- Fills and seals up to 1,200 capsules per hour
- Utilizes Capsugel's proprietary LEMS® technology for sealing which eliminates the need for banding
- Product integrity ensured with gentle handling of capsules before sealing and during the drying cycle
- Nitrogen purge available to protect against product oxidation
- A robust filling pump with highly accurate temperature control
- Numerous optional accessories available
The CFS 1200 automated filler and sealer comes with a complete installation package, including a comprehensive validation package.
CFS 1500 C Liquid Filling and Sealing Machine
Capsugel’s CFS 1500 C capsule filling and sealing machine allows for easy integration into a suitable containment system and is designed for easy cleaning. Key features include:
- Nominal throughput of 1,500 filled and sealed capsules per hour
- Weight of every capsule recorded for confidence and regulatory documentation
- 21 CFR Part 11 and cGMP compliant
- Innovative dosing pump provides increased durability and precision
- Sealing is reproducible and accurate over time: ensures consistency and reliability
- Sealing fluid dose optimized to make the system more economical
- Advanced drying system ensures air flow in the carousel and produces highly effective fusion
- Nitrogen purge available to protect against product oxidation
- Intuitive software interface with options to save liquid filling and sealing settings to increase efficiency
- Ability to store recipes for future use
- Servo control for smooth, quiet operation
- Wheel-mounted base allows for easy mobility
- All parts easily accessible and removable for cleaning
- Suitable for containment when handling potent compounds
- Various options available including a range of stirrers and dosing nozzles, hollow stirrer shaft for nitrogen purge and a spare parts kit
cGMP compliant with a totally enclosed working area designed to prevent contamination, this system is a cost effective way to handle in-house production for Capsugel’s Licaps Drug Delivery System sealing up to 1,500 capsules per hour.
Service and Support
Capsugel’s experienced service and support team will provide installation and on-site training. Ongoing support and preventive maintenance agreements are also available.
"We were very impressed with the equipment we saw, which led in the end to a successful FAT. We realized especially the tremendous effort Philippe and his team put into the project - with this professional and passionate team I am sure we will keep the tough timelines!"
- Multinational pharmaceutical company
To read more customer testimonials, click here.