Blinding Clinical Supplies Utilizing Over encapsulation
The best way to blind drugs during clinical trials is with overencapsulation. Robert Meyers and Colleen Cratty look at the best methods for overencapsulation in this "Pharmaceutical Engineering" (2003) article.
Can Automated API Dose Dispensing be Accurate at 10 µg? An Analysis of Limiting Factors
Closed loop micro-dosing is an issue in the development phase of capsule production that can be overcome with accurate, API dose dispensing. This article discusses rates, variability and other metrics involved in this process.
PCcaps™ To Speed Up Pre-clinical Trials
Features and benefits collateral on the importance of using pre-clinical animal studies in pre-clinicial formulation development stage which can speed formulations to market.
Challenges and Opportunities in the Encapsulation of Liquid and Semi-Solid Formulations into Capsules for Oral Administration
A study that compares the performance of small-scale, Phase I manufacturing of HGCs with soft gel caps. Small-scale enhancements for filling and sealing liquids and semi-solids can shorten time to first in-human.
Cross Linking of Gelatin Capsules and Its Relevance to Their In Vitro-In Vivo Performance
Bioavailability can be impacted due to cross-linking. This paper discusses the potential for cross-linking in gelatin capsules during in vivo/in vitro.
Cyclic Voltammetry as a Predictive Tool for the Selection of Antioxidants in Lipid-Based Formulations
According to this recent study, using cyclic voltammetry allows scientists to rapidly predict the excipients for anti-oxidants in lipid-based formulations.