In this study, the performance of Capsugel® Enprotect® capsules was evaluated using the DGM-intestinal model after intake in fasted and fed state and compared to
in vivo data. The findings suggest robust gastro-resistant and intestinal disintegration properties of the investigated capsules. Postprandial intake of the capsules (using two different meal types) did not compromise their gastric integrity. The predictions based on the DGM-intestinal data was in line with in vivo data, which suggests that the DGM is predictive of gastrointestinal behavior of solid oral dosage forms. Poster presented at the 5th European Conference on Pharmaceutics 2025.
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