Article
Performance Qualification of New Hypromellose Capsule Now Available
Vcaps® Plus, a new high performance hypromellose (HPMC) capsule shell which contains no gelling agent and is dissolution friendly is compared to gelatin and a HPMC capsule containing carrageenan in this two part study from Pharmaceutical Development, Wyeth Research. The results show the new capsule is superior in terms of mechanical strength, hygroscopicity and compatibility with a wide range of drugs. Based on the superior dissolution performances and quality attributes, the new hypromellose capsule was satisfactorily qualified and has since been used in nearly 20 investigational new drug (IND) compounds.